International Normalized Ratio ( Inr )
نویسنده
چکیده
Prothrombin time can be measured roughly on whole blood as in neonates, but is more commonly measured from plasma. Blood is taken into a vacutainer containing liquid citrate. Citrate acts as an anticoagulant by consuming all the calcium in the sample. The blood is mixed and centrifuged to separate blood cells from the plasma. The plasma is placed in a coagulation machine which takes a sample of the plasma. An excess of calcium is added, which enables the blood to clot again. Tissue factor or thromboplastin is added and the time taken by the sample to clot is measured optically.
منابع مشابه
Simplified method for international normalized ratio (INR) derivation based on the prothrombin time/INR line: an international study.
BACKGROUND The need to perform local International Sensitivity Index (ISI) calibrations and in particular the requirement for a manual method for prothrombin time (PT) determination, have proved to be obstacles to application of the WHO scheme for PT standardization. METHODS We used international normalized ratio (INR) derived with a set of only 5 European Concerted Action on Anticoagulation ...
متن کاملEffect of stress on international normalized ratio during warfarin therapy.
OBJECTIVE To discuss the effect of stress on the international normalized ratio (INR) when patients are taking warfarin. CASE SUMMARY Two patients at a pharmacist-managed anticoagulation clinic who were stable with anticoagulation developed elevated INR values after a stressful event occurred. All other factors known to elevate the INR were unchanged; furthermore, the INR values returned to t...
متن کاملClinical Utility and Accuracy of Coaguchek XS, a Reliable Alternative to Laboratory International Normalized Ratio Monitoring in Korean Patients With Atrial Fibrillation
Background and Objectives: To evaluate the accuracy and the clinical utility of the Coaguchek XS, a portable point-of-care coagulometer, compared to standard laboratory methods in Korean patients. Subjects and Methods: We included 107 patients with atrial fibrillation on long-term oral warfarin therapy. The prothrombin time as expressed by the international normalized ratio (INR) was measured b...
متن کاملInterpretation of serial measurements of international normalized ratio for prothrombin times in monitoring oral anticoagulant therapy.
Despite careful monitoring of oral anticoagulant treatment (OAT), some international normalized ratio (INR) for prothrombin time values will fall outside the therapeutic range. Considerable changes in serial INR results from OAT patients may be caused by random fluctuation alone, and, for statistical reasons, a fraction of the INR values will fall outside therapeutic range and interfere with do...
متن کاملCorrelation of point-of-care International Normalized Ratio to laboratory International Normalized Ratio in hemodialysis patients taking warfarin.
BACKGROUND AND OBJECTIVES To determine whether point-of-care (POC) International Normalized Ratio (INR) test results correlate with plasma INR measures in intermittent hemodialysis (IHD) patients on warfarin. Anemia is thought to reduce the accuracy of POC INR assay results. Whether POC INR testing could be implemented for hemodialysis patients on chronic warfarin, who are often anemic despite ...
متن کاملComparison of International Normalized Ratio Measurement between CoaguChek XS Plus and STA-R Coagulation Analyzers
BACKGROUND Point-of-care testing (POCT) coagulometers are increasingly being used in the hospital setting. We investigated whether the prothrombin time international normalized ratio (INR) results by CoaguChek XS Plus (Roche Diagnostics GmbH, Mannheim, Germany) can be used reliably without being confirmed with the INR results by STA-R system (Diagnostica Stago S.A.S, Asnières sur Seine, France)...
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